Mouth cancer

Mouth cancer refers to cancer that develops in any of the parts that make up the mouth. Mouth cancer can occur on the lips, gums, tongue, inside lining of the cheeks, and the roof and floor of the mouth. Cancer that occurs on the inside of the mouth is sometimes called oral cancer or oral cavity cancer. Mouth cancer is one of several types of cancer grouped in a category called head and neck cancers. Mouth cancer and other head and neck cancers are often treated similarly.

Signs and symptoms of mouth cancer may include:

A sore that doesn’t heal
A lump or thickening of the skin or lining of your mouth
A white or reddish patch on the inside of your mouth
Loose teeth
Poorly fitting dentures
Tongue pain
Jaw pain or stiffness
Difficult or painful chewing
Difficult or painful swallowing
Sore throat
Feeling that something is caught in your throat

Mouth cancer occurs when cells on your lips or in your mouth develop changes (mutations) in their DNA. These mutations allow cancer cells to grow and divide when healthy cells would die. The accumulating mouth cancer cells can form a tumor. With time they may spread to other areas of the mouth and on to other areas of the head and neck or other parts of the body. Mouth cancers most commonly begin in the flat, thin cells (squamous cells) that line your lips and the inside of your mouth. Most oral cancers are squamous cell carcinomas. It’s not clear what causes the mutations in squamous cells that lead to mouth cancer.

Factors that can increase your risk of mouth cancer include:

  • Tobacco use of any kind, including cigarettes, cigars, pipes, chewing tobacco and snuff, among others
  • Heavy alcohol use
  • Excessive sun exposure to your lips
  • A sexually transmitted virus called human papillomavirus (HPV)
  • Previous cancer or radiation treatments in the head or neck area

Tests and procedures used to diagnose mouth cancer include:

Physical exam. Your doctor or dentist will examine your lips and mouth to look for abnormalities — areas of irritation, such as sores and white patches (leukoplakia).
Biopsy. If a suspicious area is found, your doctor or dentist may remove a sample of cells for laboratory testing. Unusual cells can be scraped away with a brush or cut away using a scalpel. In the laboratory, the cells are analyzed for cancer or precancerous changes that indicate a risk of future cancer.

Once mouth cancer is diagnosed, your doctor works to determine the extent, or stage, of your cancer. Mouth cancer staging tests may include:

Using a scope to inspect your throat. During a procedure called endoscopy, your doctor may pass a lighted scope down your throat to look for signs that cancer has spread beyond your mouth.
Imaging tests. A variety of imaging tests may help determine whether cancer has spread beyond your mouth. Imaging tests may include X-rays, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and positron emission tomography (PET) scans, among others. Not everyone needs each test. Your doctor determines which tests are appropriate based on your condition.

Mouth cancer stages are indicated using Roman numerals I through IV. A lower stage, such as stage I, indicates a smaller cancer confined to one area. A higher stage, such as stage IV, indicates a larger tumor or that cancer has spread to other areas of the head or neck, or to other areas of the body. Your cancer’s stage helps your doctor determine your treatment options.

Treatment for mouth cancer depends on your cancer’s location and stage, as well as your overall health and personal preferences. You may have just one type of treatment, or you may undergo a combination of cancer treatments.

Surgery for mouth cancer may include:

Surgery to remove the tumor. Your surgeon may cut away the tumor and a margin of healthy tissue that surrounds it. Smaller cancers may be removed through minor surgery. Larger tumors may require more extensive procedures. For instance, removing a larger tumor may involve removing a section of your jawbone or a portion of your tongue.
Surgery to remove cancer that has spread to the neck. Mouth cancer often spreads to the lymph nodes in the neck. Your surgeon may recommend a procedure to remove cancerous lymph nodes and related tissue in the neck (neck dissection).
Surgery to reconstruct the mouth. After an operation to remove your cancer, your surgeon may recommend reconstructive surgery to restore the appearance of your face or to help you regain the ability to talk and eat. Your surgeon may transplant grafts of skin, muscle or bone from other parts of your body to reconstruct your face. Dental implants may replace your natural teeth.

Surgery carries a risk of bleeding and infection. Surgery for mouth cancer often affects your appearance, as well as your ability to speak, eat and swallow. Your doctor may refer you to specialists who can help you cope with these changes.

Radiation therapy
Radiation therapy uses high-energy beams, such as X-rays, to kill cancer cells. Radiation therapy can be delivered from a machine outside of your body (external beam radiation) or from radioactive seeds and wires placed near your cancer (brachytherapy). Mouth cancers are particularly sensitive to radiation therapy.

Radiation therapy may be the only treatment you receive if you have an early-stage mouth cancer. Radiation therapy can also be used before or after surgery. In other cases, radiation therapy may be combined with chemotherapy. This combination increases the effectiveness of radiation therapy, but it also increases the side effects you may experience. In cases of advanced mouth cancer, radiation therapy may help relieve signs and symptoms caused by the cancer, such as pain.

Side effects of radiation therapy to your mouth may include dry mouth, tooth decay, mouth sores, bleeding gums, jaw stiffness, fatigue and red, burn-like skin reactions.

Chemotherapy
Chemotherapy is a treatment that uses chemicals to kill cancer cells. Chemotherapy drugs can be given alone, in combination with other chemotherapy drugs or in combination with other cancer treatments. Chemotherapy may increase the effectiveness of radiation therapy, so the two are often combined.

Side effects of chemotherapy depend on which drugs you receive. Common side effects include nausea, vomiting and hair loss.

Targeted drug therapy
Targeted drugs treat mouth cancer by altering specific aspects of cancer cells that fuel their growth. Cetuximab (Erbitux) is one targeted therapy approved for treating head and neck cancers in certain situations. Cetuximab stops the action of a protein that’s found in many types of healthy cells, but is more prevalent in certain types of cancer cells.

Other targeted drugs are being studied in clinical trials. Targeted drugs can be used in combination with chemotherapy or radiation therapy.

There’s no proven way to prevent mouth cancer. However, you can reduce your risk of mouth cancer if you:

Stop using tobacco or don’t start. If you use tobacco, stop. If you don’t use tobacco, don’t start. Using tobacco, whether smoked or chewed, exposes the cells in your mouth to dangerous cancer-causing chemicals.
Drink alcohol only in moderation, if at all. Chronic excessive alcohol use can irritate the cells in your mouth, making them vulnerable to mouth cancer. If you choose to drink alcohol, limit yourself to one drink a day if you’re a woman or older than age 65. Men should drink no more than two drinks a day.
Eat a variety of fruits and vegetables. Choose a diet rich in fruits and vegetables. The vitamins and antioxidants found in fruits and vegetables may help reduce your risk of mouth cancer.
Avoid excessive sun exposure to your lips. Protect the skin on your lips from the sun by staying in the shade when possible. Wear a broad-brimmed hat that effectively shades your entire face, including your mouth. Apply a sunscreen lip product as part of your routine sun protection regimen.
See your dentist regularly. As part of a routine dental exam, ask your dentist to inspect your entire mouth for abnormal areas that may indicate mouth cancer or precancerous changes.

Mouth cancers are closely linked to tobacco use, including cigarettes, cigars, pipes, chewing tobacco and snuff, among others. Not everyone who is diagnosed with mouth cancer uses tobacco. But if you do, now is the time to stop because:

  • Tobacco use makes treatment less effective.
  • Tobacco use makes it harder for your body to heal after surgery.
  • Tobacco use increases your risk of getting another cancer in the future.

Quitting smoking or chewing can be very difficult. And it’s that much harder when you’re trying to cope with a stressful situation, such as a cancer diagnosis. Your doctor can discuss all of your options, including medications, nicotine replacement products and counseling.

Alcohol, particularly when combined with tobacco use, greatly increases the risk of mouth cancer. If you drink alcohol, stop now. This may help reduce your risk of a second cancer. Stopping drinking may also help you better tolerate your mouth cancer treatments.